Source: http://www.thehollywoodgossip.com/2013/04/kim-kardashian-still-obsessed-with-kate-middleton/
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Thursday, April 11, 2013
Syrian militants pledge allegiance to al-Qaida
BEIRUT (AP) ? The leader of an Islamic extremist rebel group in Syria pledged allegiance on Wednesday to al-Qaida and its leader for the first time.
Abu Mohammad al-Golani, head of Jabhat al-Nusra or the Nusra Front, confirmed his rebel group was tied to al-Qaida in Iraq in an audio message posted on militant websites.
Al-Qaida in Iraq said Tuesday it had joined forces with the Nusra Front ? the most effective of a disparate patchwork of rebel groups fighting to topple Syrian President Bashar Assad. He said the new alliance would be called the Islamic State in Iraq and the Levant.
The Levant is the traditional name referring to the region from southern Turkey to Egypt on the eastern Mediterranean.
However, al-Golani said he was not consulted ahead of the merger announcement. He did not deny they had merged, but left the point unclear.
He said the leadership of Nusra Front "was not aware of this announcement and heard about only it through media outlets. If the speech is true, we were not asked or consulted on it."
The alliance, if confirmed, would be an even stronger opponent in the fight to topple Assad and become a dominant player in what eventually replaces his regime.
The merger was announced by Abu Bakr al-Baghdadi, the leader of the Islamic State of Iraq or al-Qaida in Iraq. His 21-minute audio message was posted on militant websites late Monday.
A website linked to Nusra Front known as al-Muhajir al-Islami ? the Islamic emigrant ? confirmed the merger.
But al-Golani said the announcement was premature and that his group will continue to use Jabhat al-Nusra as its name.
"The banner of the Front will remain unchanged despite our pride in the banner of the State and those who carried it and sacrificed and shed their blood for it," he said in a reference to al-Qaida in Iraq.
Al-Golani's message was first reported by the SITE monitoring service for militant groups.
In the audio message, he pledged allegiance to the leader of the al-Qaida terror network, Ayman al-Zawahri.
Earlier this week, al-Zawahiri urged Islamic fighters in Syria to unite in their efforts to oust Assad.
Nusra Front, which has welcomed militants from across the Muslim world into its ranks, has made little secret of its links across the Iraqi border. But until now, it has not officially declared itself to be part of al-Qaida.
In the recording, al-Golani acknowledges his followers receive assistance and training from al-Qaida in Iraq.
The Syrian group, which wants to oust Assad and replace his regime with an Islamic state, first emerged in a video posted online in January 2012. Since then, it has demonstrated its prowess ? and ruthlessness ? on the battlefield.
It has claimed responsibility for many of the deadliest suicide bombings against Syrian government institutions and military facilities. The group's success helped fuel a surge in its popularity among rebel fighters, although it has also emerged as a source of friction with more moderate and secular brigades in Syria.
The group also has tried to provide basic services in the parts of northern Syria under rebel control, including security and food to civilians struggling to survive.
Source: http://news.yahoo.com/syrian-militants-pledge-allegiance-al-qaida-135156948.html
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Wednesday, April 10, 2013
Engineered T cells kill tumors but spare normal tissue in an animal model
Monday, April 8, 2013
The need to distinguish between normal cells and tumor cells is a feature that has been long sought for most types of cancer drugs. Tumor antigens, unique proteins on the surface of a tumor, are potential targets for a normal immune response against cancer. Identifying which antigens a patient's tumor cells express is the cornerstone of designing cancer therapy for that individual. But some of these tumor antigens are also expressed on normal cells, inching personalized therapy back to the original problem.
T cells made to express a protein called CAR, for chimeric antigen receptor, are engineered by grafting a portion of a tumor-specific antibody onto an immune cell, allowing them to recognize antigens on the cell surface. Early first-generation CARs had one signaling domain for T-cell activation. Second-generation CARs are more commonly used and have two signaling domains within the immune cell, one for T-cell activation and another for T- cell costimulation to boost the T cell's function.
Importantly, CARs allow patients' T cells to recognize tumor antigens and kill certain tumor cells. A large number of tumor-specific, cancer-fighting CAR T cells can be generated in a specialized lab using patients' own T cells, which are then infused back into them for therapy. Despite promising clinical results, it is now recognized that some CAR-based therapies may involve toxicity against normal tissues that express low amounts of the targeted tumor-associated antigen.
To address this issue, Daniel J. Powell Jr., PhD, research assistant professor of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, and director of the Cellular Therapy Tissue Facility, developed an innovative dual CAR approach in which the activation signal for T cells is physically dissociated from a second costimulatory signal for immune cells. The two CARs carry different antigen specificity -- mesothelin and a-folate receptor. Mesothelin is primarily associated with mesothelioma and ovarian cancer, and a-folate receptor with ovarian cancer.
Powell likens this dual CAR approach to having two different gas pedals, one for starting the immune system and a second for revving it up. Dual CAR T cells are more selective for tumor cells since their full activity requires interaction with both antigens, which are only co-expressed on tumor cells, not normal tissue.
Dual CAR T cells showed weak cytokine production against target cells expressing only one tumor-associated antigen in lab assays, similar to first-generation CAR T cells bearing the CD3 activation domain only, but demonstrated enhanced cytokine production upon encountering natural or engineered tumor cells expressing both antigens, equivalent to second-generation CAR T cells with dual, but unseparated signaling.
In a mouse model of human ovarian cancer, T cells with the dual-signaling CARs persisted at high numbers in the blood, accumulated in tumors, and showed potent anti-cancer activity against human tumors. Dual CAR T cells were equivalent to second-generation CAR T cells in activity against tumors bearing two antigens. However, the dual-signaling CAR T cells did not react vigorously with normal tissue expressing one antigen while second- generation CAR T cells did.
"This new dual-specificity CAR approach can enhance the therapeutic efficacy of CAR T cells against cancer while minimizing reactivity against normal tissues," says Powell.
Their findings have been published in the inaugural issue of Cancer Immunology Research, the newest journal from the American Association for Cancer Research.
###
University of Pennsylvania School of Medicine: http://www.uphs.upenn.edu/news/
Thanks to University of Pennsylvania School of Medicine for this article.
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Tuesday, April 9, 2013
UAE man jailed 10 months for tweeting on father's trial
DUBAI (Reuters) - A court in the United Arab Emirates sentenced a man to 10 months in jail on Monday after he tweeted details of the trial of his father and 93 other people accused of plotting to seize power in the Gulf Arab state, an Emirati activist said.
Human Rights Watch (HRW) said last week that Abdulla al-Hadidi was arrested on March 21 on charges of publishing "in bad faith" false details of a public trial session on the Internet.
The day before the arrest, officials from the Federal Supreme Court in Abu Dhabi had informed Hadidi and several other relatives of the defendants family members would no longer be allowed to attend the trial, HRW said.
Rights groups urged UAE authorities to grant full public access to the trial. A source close to the UAE government has said the trial was taking place in a "very transparent manner".
UAE newspapers have said the defendants belong to al-Islah, a local Islamist group which says it wants peaceful reform.
Emirati activist Ahmed Mansoor said the Abu Dhabi court found Hadidi guilty of publishing on Twitter "with bad intent" what happened at the hearing. But the court acquitted him of using force and violence with public officials during the trial.
Mansoor, who said he had spoken to one of the lawyers involved in the case, told Reuters Hadidi's attorney would appeal the sentence.
A source close to the UAE government said it "is not our practice to comment on court deliberations and rulings".
The state news agency WAM in January quoted the attorney general, Salem Saeed Kubaish, as saying that members of the group had sought to penetrate institutions of the state, including schools, universities and ministries.
The defendants are accused of "belonging to an illegal, secret organization ... that aims to counter the foundations of this state in order to seize power and of contacting foreign entities and groups to implement this plan," WAM said.
(Writing by Yara Bayoumy; Editing by Sami Aboudi and Robin Pomeroy)
Source: http://news.yahoo.com/uae-man-jailed-10-months-tweeting-fathers-trial-185328857.html
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